Canine hemophilia and hemopoietic grafting.

Two hemophilic beagles were given normal sibling. During observation 1200 A whole-body irradiation followed periods of 7 and 24 mo, there was no by a successful marrow graft from a evidence of factor VIII synthesis. ORTHOTOPIC TRANSPLANTATION of a normal liver into a hemophilic dog results in complete correction of the deficiency of factor VIII.”3 However, there are significant extrahepatic sources of factor VIII, since hepatectomized normal dogs bearing a transplanted liver from a hemophilic animal show factor VIII levels equivalent to that seen in the heterozygous state.2 3